Dynamic changes and clinical significance of serum IMD and PCT in patients with acute pancreatitis

To explore dynamic changes and clinical significance of serum IMD and PCT in patients with acute pancreatitis. According to acute pancreatitis guide, patients with acute pancreatitis were divided into mild acute pancreatitis (MAP group, n = 60) and severe acute pancreatitis (SAP group, n = 30). Serum IMD and serum PCT contents in MAP group and SAP group were detected in 24 hours, 48 hours, 72 hours and 7 days after admission, meanwhile APACHE II score was recorded within 24 hours; Healthy people in the same period were taken as the control group (NS group, n = 30); changes and differences in serum IMD and serum PCT were compared. Correlation analysis of serum IMD and PCT, IMD and APACHE II scores, PCT and APACHE II scores was performed. In MAP group and SAP group, PCT content increased over time, and the difference was significant (P < 0.05); PCT content in SAP group was significantly higher than that in MAP group; IMD content in MAP group and SAP group decreased over time; the difference was significant (P); IMD content in SAP group was significantly lower than that in the MAP group, and the difference was significant (P < 0.05); serum IMD content had a negative correlation with PCT, with a certain value for acute pancreatitis diagnosis; serum IMD content was negatively correlated with APACHE II score in MAP group and SAP group (rs < 0, P < 0.05). Serum PCT content showed a positive correlation with APACHE II score in MAP group and SAP group (rs > 0, P < 0.05). Serum IMD and PCT can be used as indicators of early diagnosis of acute pancreatitis, and also have a certain value in severe pancreatitis diagnosis.